His current research is focused on energy efficient and mobile computing issues in embedded systems. He is author/co-author of over 150 articles on various aspects of embedded systems and design automation and four patents on PLL design, data-path synthesis and system-on-chip modeling.

Gupta is a recipient of the Chancellor's Fellow at UC Irvine, UCI Chancellor's Award for excellence in undergraduate research, National Science Foundation CAREER Award, two Departmental Achievement Awards and a Components Research Team Award at Intel.

Gupta served as founding Chair of the ACM/IEEE Conference on Models and Methods in Codesign (MEMOCODE) and founding Co-Chair of ACM/IEEE/IFIP Conference on Codesign and System Synthesis (CODES+ISSS). Gupta is editor-in-chief of IEEE Design & Test of Computers and serves on the editorial boards of IEEE Transactions on CAD and IEEE Transactions on Mobile Computing. He serves as the VP of Publications of the IEEE Council on Electronic Design Automation (CEDA). Gupta is a Fellow of the IEEE and a distinguished lecturer for the ACM/SIGDA and the IEEE CAS Society.

Gupta serves as an advisor to Tallwood Venture Capital, RealIntent, Calypto and Packet Digital Corporation.